This gene encodes a protein that contains a coiled-coil domain. Naturally occurring mutations in this gene are associated with leprosy. [provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for CCDC122. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC122 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC122, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:43,122,454–43,123,156 | 756.8 kb | Distal (>10kb) Multiome HiCAR | 157 | |
| chr13:43,785,602–43,787,824 | 93.7 kb | Distal (>10kb) Multiome | 539 | |
| chr13:43,878,973–43,880,447 | 10 bp | At TSS Multiome | 799 | |
| chr13:44,078,845–44,079,278 | 199.4 kb | Distal (>10kb) Multiome | 56 | |
| chr13:44,108,414–44,108,986 | 229.1 kb | Distal (>10kb) Multiome | 389 | |
| chr13:44,141,321–44,142,793 | 262.4 kb | Distal (>10kb) Multiome | 822 |
Genomic view of the CCDC122 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.