Enables several functions, including 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NADPH binding activity; and NADPH dehydrogenase (quinone) activity. Involved in fatty acid biosynthetic process; glycoside metabolic process; and protein tetramerization. Located in mitochondrial matrix. Part of oxidoreductase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CBR4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CBR4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CBR4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:168,776,999–168,778,122 | 232.7 kb | Distal (>10kb) Multiome | 197 | |
| chr4:168,784,585–168,785,381 | 225.2 kb | Distal (>10kb) Multiome | 118 | |
| chr4:168,791,031–168,792,300 | 218.7 kb | Distal (>10kb) Multiome | 100 | |
| chr4:168,831,537–168,833,615 | 178.2 kb | Distal (>10kb) Multiome | 717 | |
| chr4:168,840,956–168,841,663 | 169.0 kb | Distal (>10kb) Multiome | 151 | |
| chr4:168,877,483–168,878,555 | 132.3 kb | Distal (>10kb) Multiome | 268 | |
| chr4:169,005,268–169,005,969 | 818 bp | At TSS | 186 | |
| chr4:169,009,429–169,010,942 | 75 bp | At TSS Multiome | 829 | |
| chr4:169,015,982–169,016,952 | 9.2 kb | Proximal (<10kb) | 314 | |
| chr4:169,017,814–169,018,427 | 7.6 kb | Proximal (<10kb) | 110 | |
| chr4:169,069,656–169,070,749 | 60.0 kb | Distal (>10kb) Multiome | 482 | |
| chr4:169,100,408–169,101,097 | 90.5 kb | Distal (>10kb) Multiome | 151 | |
| chr4:169,270,015–169,271,998 | 260.8 kb | Distal (>10kb) Multiome | 735 |
Genomic view of the CBR4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.