This gene encodes a protein containing two coiled-coil regions. The encoded protein promotes Rho/ROCK (Rho-kinase) signaling in cardiac muscles cells, and may facilitate myofibrillar organization. [provided by RefSeq, Jun 2013]
Transcription factors with Perturb-seq knockdown data for CAVIN4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAVIN4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAVIN4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:100,352,182–100,353,419 | 225.1 kb | Distal (>10kb) Multiome | 937 | |
| chr9:100,411,250–100,412,233 | 166.3 kb | Distal (>10kb) Multiome | 544 | |
| chr9:100,426,556–100,428,087 | 150.8 kb | Distal (>10kb) Multiome | 680 | |
| chr9:100,472,600–100,475,134 | 105.0 kb | Distal (>10kb) Multiome | 501 | |
| chr9:100,567,051–100,567,983 | 10.6 kb | Distal (>10kb) Multiome | 147 | |
| chr9:100,598,220–100,599,238 | 20.7 kb | Distal (>10kb) Multiome | 517 | |
| chr9:100,637,622–100,638,453 | 59.9 kb | Distal (>10kb) Multiome | 112 | |
| chr9:100,664,438–100,664,921 | 86.7 kb | Distal (>10kb) Multiome | 46 | |
| chr9:100,850,698–100,851,787 | 273.1 kb | Distal (>10kb) Multiome | 147 |
Genomic view of the CAVIN4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.