This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for CAVIN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAVIN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAVIN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:42,154,717–42,156,309 | 268.1 kb | Distal (>10kb) Multiome | 770 | |
| chr17:42,180,242–42,180,762 | 242.9 kb | Distal (>10kb) Multiome | 576 | |
| chr17:42,183,755–42,184,761 | 239.0 kb | Distal (>10kb) Multiome | 810 | |
| chr17:42,275,506–42,277,052 | 146.9 kb | Distal (>10kb) Multiome | 892 | |
| chr17:42,288,257–42,288,808 | 134.7 kb | Distal (>10kb) Multiome | 449 | |
| chr17:42,312,237–42,312,887 | 110.8 kb | Distal (>10kb) Multiome | 774 | |
| chr17:42,387,693–42,389,289 | 34.6 kb | Distal (>10kb) Multiome | 1178 | |
| chr17:42,422,618–42,423,513 | 54 bp | At TSS Multiome | 765 | |
| chr17:42,535,863–42,536,855 | 113.1 kb | Distal (>10kb) Multiome | 987 | |
| chr17:42,547,934–42,548,909 | 125.2 kb | Distal (>10kb) Multiome | 325 | |
| chr17:42,554,285–42,555,164 | 131.5 kb | Distal (>10kb) Multiome | 899 | |
| chr17:42,561,770–42,562,376 | 138.8 kb | Distal (>10kb) Multiome | 905 | |
| chr17:42,566,552–42,567,732 | 143.8 kb | Distal (>10kb) Multiome | 902 | |
| chr17:42,577,421–42,578,281 | 154.5 kb | Distal (>10kb) Multiome | 884 | |
| chr17:42,578,382–42,578,892 | 155.4 kb | Distal (>10kb) Multiome | 477 | |
| chr17:42,608,764–42,610,335 | 186.2 kb | Distal (>10kb) Multiome | 909 | |
| chr17:42,658,938–42,659,852 | 236.1 kb | Distal (>10kb) Multiome | 734 | |
| chr17:42,669,472–42,671,112 | 247.5 kb | Distal (>10kb) Multiome | 230 | |
| chr17:42,673,584–42,674,462 | 250.7 kb | Distal (>10kb) Multiome | 296 | |
| chr17:42,674,847–42,675,579 | 252.0 kb | Distal (>10kb) Multiome | 194 | |
| chr17:42,676,055–42,678,790 | 255.1 kb | Distal (>10kb) Multiome | 1070 | |
| chr17:42,679,005–42,680,519 | 256.7 kb | Distal (>10kb) Multiome | 654 | |
| chr17:42,682,736–42,683,400 | 259.5 kb | Distal (>10kb) Multiome | 480 |
Genomic view of the CAVIN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.