This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015]
Transcription factors with Perturb-seq knockdown data for CASP6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CASP6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CASP6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:109,419,054–109,420,658 | 283.6 kb | Distal (>10kb) Multiome HiCAR | 227 | |
| chr4:109,433,232–109,434,512 | 269.7 kb | Distal (>10kb) Multiome | 802 | |
| chr4:109,559,632–109,561,390 | 143.3 kb | Distal (>10kb) Multiome | 756 | |
| chr4:109,699,985–109,700,141 | 3.3 kb | Proximal (<10kb) | 15 | |
| chr4:109,701,412–109,703,899 | 62 bp | At TSS Multiome | 799 | |
| chr4:109,729,247–109,730,761 | 26.6 kb | Distal (>10kb) Multiome | 793 | |
| chr4:109,814,867–109,816,081 | 112.1 kb | Distal (>10kb) Multiome | 846 | |
| chr4:109,846,257–109,847,050 | 143.2 kb | Distal (>10kb) Multiome | 131 | |
| chr4:109,928,231–109,928,964 | 225.1 kb | Distal (>10kb) Multiome | 114 |
Genomic view of the CASP6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.