This gene encodes a large protein that contains six ankyrin repeats, as well as a Src homology 3 (SH3) domain and two sterile alpha motif (SAM) domains, which may be involved in protein-protein interactions. The C-terminal portion of this protein is proline-rich and contains a conserved region. A related protein interacts with calcium/calmodulin-dependent serine protein kinase (CASK). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Transcription factors with Perturb-seq knockdown data for CASKIN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CASKIN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CASKIN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:75,240,373–75,240,941 | 274.9 kb | Distal (>10kb) Multiome | 436 | |
| chr17:75,261,304–75,262,404 | 253.8 kb | Distal (>10kb) Multiome | 983 | |
| chr17:75,270,231–75,271,942 | 244.3 kb | Distal (>10kb) Multiome | 946 | |
| chr17:75,288,761–75,289,874 | 226.0 kb | Distal (>10kb) Multiome | 941 | |
| chr17:75,393,479–75,394,300 | 121.6 kb | Distal (>10kb) Multiome | 834 | |
| chr17:75,404,856–75,406,161 | 109.8 kb | Distal (>10kb) Multiome | 917 | |
| chr17:75,456,149–75,457,264 | 58.9 kb | Distal (>10kb) Multiome | 865 | |
| chr17:75,514,425–75,517,171 | 116 bp | At TSS Multiome | 1158 | |
| chr17:75,524,764–75,527,160 | 10.0 kb | Proximal (<10kb) Multiome | 951 | |
| chr17:75,549,465–75,550,388 | 34.3 kb | Distal (>10kb) Multiome | 602 | |
| chr17:75,587,697–75,590,735 | 73.8 kb | Distal (>10kb) Multiome | 744 | |
| chr17:75,633,694–75,634,328 | 118.5 kb | Distal (>10kb) Multiome | 559 | |
| chr17:75,666,763–75,667,767 | 151.7 kb | Distal (>10kb) Multiome | 783 | |
| chr17:75,720,933–75,721,693 | 205.8 kb | Distal (>10kb) Multiome | 509 | |
| chr17:75,753,534–75,754,285 | 238.3 kb | Distal (>10kb) Multiome | 699 | |
| chr17:75,764,621–75,765,674 | 249.6 kb | Distal (>10kb) Multiome | 769 | |
| chr17:75,778,786–75,780,191 | 264.3 kb | Distal (>10kb) Multiome | 1118 | |
| chr17:75,784,060–75,785,640 | 269.4 kb | Distal (>10kb) Multiome | 1176 |
Genomic view of the CASKIN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.