Enables N-acetylneuraminate 9-O-acetyltransferase activity. Involved in carbohydrate metabolic process. Located in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CASD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CASD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CASD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:94,223,393–94,224,331 | 286.0 kb | Distal (>10kb) Multiome | 298 | |
| chr7:94,307,449–94,308,049 | 202.0 kb | Distal (>10kb) Multiome | 51 | |
| chr7:94,338,572–94,339,474 | 170.8 kb | Distal (>10kb) Multiome | 144 | |
| chr7:94,374,301–94,375,925 | 134.4 kb | Distal (>10kb) Multiome | 250 | |
| chr7:94,393,359–94,395,729 | 115.2 kb | Distal (>10kb) Multiome | 479 | |
| chr7:94,509,249–94,510,982 | 242 bp | At TSS Multiome | 908 | |
| chr7:94,514,217–94,514,860 | 4.4 kb | Proximal (<10kb) | 56 | |
| chr7:94,515,409–94,515,775 | 5.6 kb | Proximal (<10kb) | 33 | |
| chr7:94,517,104–94,518,155 | 8.1 kb | Proximal (<10kb) Multiome | 58 | |
| chr7:94,655,105–94,659,080 | 148.4 kb | Distal (>10kb) Multiome | 828 | |
| chr7:95,434,366–95,435,612 | 925.2 kb | Distal (>10kb) Multiome HiCAR | 839 |
Genomic view of the CASD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.