Predicted to enable CARD domain binding activity. Predicted to be involved in negative regulation of canonical NF-kappaB signal transduction. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CARD19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CARD19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CARD19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:92,808,165–92,809,496 | 287.2 kb | Distal (>10kb) Multiome | 398 | |
| chr9:92,877,587–92,878,337 | 218.1 kb | Distal (>10kb) Multiome | 591 | |
| chr9:93,058,154–93,059,241 | 37.6 kb | Distal (>10kb) Multiome | 417 | |
| chr9:93,094,880–93,097,281 | 309 bp | At TSS Multiome | 813 | |
| chr9:93,133,298–93,134,791 | 38.0 kb | Distal (>10kb) Multiome | 796 | |
| chr9:93,159,802–93,160,270 | 63.9 kb | Distal (>10kb) Multiome | 500 | |
| chr9:93,183,782–93,185,608 | 87.9 kb | Distal (>10kb) Multiome | 401 | |
| chr9:93,346,091–93,346,711 | 250.1 kb | Distal (>10kb) Multiome | 137 | |
| chr9:93,364,969–93,366,461 | 269.5 kb | Distal (>10kb) Multiome | 123 |
Genomic view of the CARD19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.