CAPZA1
capping actin protein of muscle Z-line subunit alpha 1 | CAPPA1

CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008]

Developmental clusters: GC5
Biological processes 23 terms
F-actin capping protein complex (GO:0008290)F-actin capping protein complex (GO:0008290)F-actin capping protein complex (GO:0008290)WASH complex (GO:0071203)actin binding (GO:0003779)actin cytoskeleton (GO:0015629)actin cytoskeleton (GO:0015629)actin cytoskeleton organization (GO:0030036)actin filament binding (GO:0051015)barbed-end actin filament capping (GO:0051016)barbed-end actin filament capping (GO:0051016)barbed-end actin filament capping (GO:0051016)cadherin binding (GO:0045296)cell junction assembly (GO:0034329)cortical cytoskeleton (GO:0030863)cytoskeleton (GO:0005856)cytoskeleton (GO:0005856)cytosol (GO:0005829)cytosol (GO:0005829)extracellular exosome (GO:0070062)extracellular region (GO:0005576)protein binding (GO:0005515)protein-containing complex assembly (GO:0065003)
Expression (TPM)
CAPZA1 — as a Regulated Gene

TFs regulating CAPZA1 0 TFs

Transcription factors with Perturb-seq knockdown data for CAPZA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAPZA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to CAPZA1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAPZA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:112,369,701–112,370,152 250.0 kb Distal (>10kb) Multiome 364
chr1:112,390,678–112,391,531 228.8 kb Distal (>10kb) Multiome 470
chr1:112,395,753–112,396,890 223.6 kb Distal (>10kb) Multiome 600
chr1:112,465,931–112,466,532 153.5 kb Distal (>10kb) Multiome 686
chr1:112,501,804–112,502,551 117.6 kb Distal (>10kb) Multiome 420
chr1:112,507,925–112,508,314 111.8 kb Distal (>10kb) Multiome 122
chr1:112,508,429–112,509,558 110.8 kb Distal (>10kb) Multiome 413
chr1:112,524,298–112,524,779 95.3 kb Distal (>10kb) Multiome 127
chr1:112,618,652–112,620,129 46 bp At TSS Multiome 956
chr1:112,674,125–112,675,737 55.6 kb Distal (>10kb) Multiome 910
chr1:112,700,203–112,701,476 81.0 kb Distal (>10kb) Multiome 765
chr1:112,704,514–112,705,591 85.4 kb Distal (>10kb) Multiome 694
chr1:112,706,536–112,707,966 87.5 kb Distal (>10kb) Multiome 784
chr1:112,714,149–112,716,774 96.8 kb Distal (>10kb) Multiome 765
chr1:112,743,679–112,744,585 124.4 kb Distal (>10kb) Multiome 198
chr1:112,790,881–112,791,569 171.5 kb Distal (>10kb) Multiome 158
chr1:112,794,180–112,795,498 175.3 kb Distal (>10kb) Multiome 251
chr1:112,809,091–112,810,187 189.9 kb Distal (>10kb) Multiome 445
chr1:112,817,716–112,818,473 198.3 kb Distal (>10kb) Multiome 249
chr1:112,819,120–112,820,730 199.6 kb Distal (>10kb) Multiome 456
chr1:112,825,474–112,826,954 206.1 kb Distal (>10kb) Multiome 182
chr1:112,841,024–112,841,798 221.6 kb Distal (>10kb) Multiome 215
chr1:112,849,324–112,850,157 230.0 kb Distal (>10kb) Multiome 352

Genome Browser

Genomic view of the CAPZA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:112,359,701 – 112,860,157
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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