This gene encodes a protein containing zinc-finger-like repeats and a calpain-like protease domain. The encoded protein may function as a transcription factor, RNA-binding protein, or in protein-protein interactions during visual system development. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CAPN15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAPN15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAPN15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:228,869–229,598 | 298.4 kb | Distal (>10kb) Multiome | 1035 | |
| chr16:234,152–235,669 | 292.9 kb | Distal (>10kb) Multiome | 908 | |
| chr16:351,804–354,436 | 174.8 kb | Distal (>10kb) Multiome | 654 | |
| chr16:378,999–379,813 | 148.3 kb | Distal (>10kb) Multiome | 225 | |
| chr16:380,836–382,614 | 145.7 kb | Distal (>10kb) Multiome HiCAR | 634 | |
| chr16:383,438–384,218 | 143.9 kb | Distal (>10kb) Multiome HiCAR | 342 | |
| chr16:396,893–397,640 | 130.2 kb | Distal (>10kb) Multiome HiCAR | 496 | |
| chr16:401,380–402,199 | 125.9 kb | Distal (>10kb) Multiome HiCAR | 818 | |
| chr16:424,888–426,136 | 102.1 kb | Distal (>10kb) Multiome | 752 | |
| chr16:483,333–484,000 | 44.0 kb | Distal (>10kb) Multiome | 143 | |
| chr16:526,749–528,601 | 120 bp | At TSS Multiome | 811 | |
| chr16:569,530–570,338 | 42.1 kb | Distal (>10kb) Multiome | 492 | |
| chr16:578,896–579,353 | 51.4 kb | Distal (>10kb) Multiome | 511 | |
| chr16:588,593–590,724 | 62.2 kb | Distal (>10kb) Multiome | 853 | |
| chr16:635,900–638,127 | 108.6 kb | Distal (>10kb) Multiome | 1021 | |
| chr16:641,491–643,007 | 114.2 kb | Distal (>10kb) Multiome | 856 | |
| chr16:648,795–649,829 | 121.6 kb | Distal (>10kb) Multiome | 862 | |
| chr16:660,457–661,656 | 133.2 kb | Distal (>10kb) Multiome | 456 | |
| chr16:667,633–668,442 | 140.3 kb | Distal (>10kb) Multiome | 838 | |
| chr16:678,847–681,585 | 152.3 kb | Distal (>10kb) Multiome | 803 | |
| chr16:683,618–684,859 | 156.7 kb | Distal (>10kb) Multiome | 701 | |
| chr16:694,897–695,485 | 167.7 kb | Distal (>10kb) Multiome | 390 | |
| chr16:705,242–706,468 | 178.3 kb | Distal (>10kb) Multiome | 248 | |
| chr16:714,577–716,048 | 187.4 kb | Distal (>10kb) Multiome | 555 | |
| chr16:720,434–721,963 | 193.6 kb | Distal (>10kb) Multiome | 966 | |
| chr16:726,310–729,144 | 199.3 kb | Distal (>10kb) Multiome | 736 | |
| chr16:740,359–741,596 | 213.4 kb | Distal (>10kb) Multiome | 897 | |
| chr16:787,564–789,160 | 260.8 kb | Distal (>10kb) Multiome | 635 | |
| chr16:807,352–808,044 | 280.1 kb | Distal (>10kb) Multiome | 600 | |
| chr16:813,330–813,960 | 286.1 kb | Distal (>10kb) Multiome | 325 |
Genomic view of the CAPN15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.