Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for CAPN10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAPN10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAPN10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:240,434,652–240,436,967 | 151.3 kb | Distal (>10kb) Multiome | 516 | |
| chr2:240,452,173–240,453,282 | 134.1 kb | Distal (>10kb) Multiome | 285 | |
| chr2:240,557,164–240,558,401 | 28.7 kb | Distal (>10kb) Multiome | 226 | |
| chr2:240,560,183–240,561,566 | 26.5 kb | Distal (>10kb) Multiome | 1021 | |
| chr2:240,566,043–240,567,010 | 20.2 kb | Distal (>10kb) Multiome | 749 | |
| chr2:240,567,779–240,569,178 | 18.4 kb | Distal (>10kb) Multiome | 615 | |
| chr2:240,586,073–240,587,459 | 184 bp | At TSS Multiome | 893 | |
| chr2:240,595,721–240,595,927 | 8.9 kb | Proximal (<10kb) | 112 | |
| chr2:240,670,022–240,670,734 | 83.6 kb | Distal (>10kb) Multiome | 19 | |
| chr2:240,818,573–240,821,401 | 232.3 kb | Distal (>10kb) Multiome | 419 | |
| chr2:240,832,084–240,832,795 | 245.7 kb | Distal (>10kb) Multiome | 307 |
Genomic view of the CAPN10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.