This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene.[provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for CANT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CANT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CANT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:78,723,107–78,723,697 | 286.3 kb | Distal (>10kb) Multiome | 236 | |
| chr17:78,781,367–78,783,044 | 227.3 kb | Distal (>10kb) Multiome | 847 | |
| chr17:78,839,825–78,841,566 | 168.8 kb | Distal (>10kb) Multiome | 1124 | |
| chr17:78,924,768–78,925,859 | 84.3 kb | Distal (>10kb) Multiome | 498 | |
| chr17:78,971,335–78,971,892 | 38.2 kb | Distal (>10kb) Multiome | 359 | |
| chr17:79,009,356–79,010,250 | 60 bp | At TSS Multiome | 703 | |
| chr17:79,023,888–79,024,662 | 14.6 kb | Distal (>10kb) Multiome | 348 | |
| chr17:79,074,462–79,075,529 | 65.1 kb | Distal (>10kb) Multiome | 657 | |
| chr17:79,182,908–79,183,922 | 173.8 kb | Distal (>10kb) Multiome | 257 |
Genomic view of the CANT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.