Predicted to enable TBP-class protein binding activity. Predicted to be involved in SCF complex assembly; positive regulation of DNA-templated transcription; and protein ubiquitination. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CAND2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAND2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAND2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:12,556,440–12,557,557 | 239.6 kb | Distal (>10kb) Multiome | 1025 | |
| chr3:12,663,393–12,664,764 | 132.5 kb | Distal (>10kb) Multiome | 941 | |
| chr3:12,768,768–12,769,541 | 27.6 kb | Distal (>10kb) Multiome | 69 | |
| chr3:12,796,430–12,797,162 | 174 bp | At TSS Multiome | 467 | |
| chr3:12,809,737–12,810,783 | 13.7 kb | Distal (>10kb) Multiome | 598 | |
| chr3:12,833,218–12,834,303 | 36.9 kb | Distal (>10kb) Multiome | 191 | |
| chr3:12,841,044–12,841,991 | 45.0 kb | Distal (>10kb) Multiome | 956 | |
| chr3:12,868,442–12,869,473 | 72.4 kb | Distal (>10kb) Multiome | 404 | |
| chr3:12,875,773–12,876,581 | 79.5 kb | Distal (>10kb) Multiome | 256 | |
| chr3:12,966,894–12,968,388 | 171.2 kb | Distal (>10kb) Multiome | 677 | |
| chr3:12,993,065–12,995,303 | 198.4 kb | Distal (>10kb) Multiome | 920 |
Genomic view of the CAND2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.