The protein encoded by this gene contains a CG1 DNA-binding domain, a transcription factor immunoglobulin domain, ankyrin repeats, and calmodulin-binding IQ motifs. The encoded protein is thought to be a transcription factor and may be a tumor suppressor. However, a translocation event is sometimes observed between this gene and the WWTR1 gene, with the resulting WWTR1-CAMTA1 oncoprotein leading to epithelioid hemangioendothelioma, a malignant vascular cancer. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for CAMTA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAMTA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAMTA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:6,486,194–6,486,953 | 298.8 kb | Distal (>10kb) Multiome | 416 | |
| chr1:6,489,772–6,491,050 | 295.3 kb | Distal (>10kb) Multiome | 676 | |
| chr1:6,497,162–6,497,841 | 287.9 kb | Distal (>10kb) Multiome | 324 | |
| chr1:6,554,053–6,554,774 | 230.9 kb | Distal (>10kb) Multiome | 897 | |
| chr1:6,579,406–6,580,453 | 205.5 kb | Distal (>10kb) Multiome | 684 | |
| chr1:6,601,460–6,604,144 | 182.5 kb | Distal (>10kb) Multiome | 1062 | |
| chr1:6,612,539–6,615,225 | 171.9 kb | Distal (>10kb) Multiome | 806 | |
| chr1:6,624,591–6,625,845 | 160.2 kb | Distal (>10kb) Multiome | 730 | |
| chr1:6,701,304–6,702,223 | 83.6 kb | Distal (>10kb) Multiome | 1025 | |
| chr1:6,784,205–6,786,365 | 287 bp | At TSS Multiome | 950 | |
| chr1:6,961,705–6,964,510 | 177.5 kb | Distal (>10kb) Multiome | 485 | |
| chr1:7,069,944–7,070,356 | 284.9 kb | Distal (>10kb) Multiome | 59 | |
| chr1:7,550,192–7,550,887 | 765.2 kb | Distal (>10kb) Multiome | 119 | |
| chr1:7,667,425–7,668,031 | 882.3 kb | Distal (>10kb) Multiome | 391 | |
| chr1:7,669,374–7,669,989 | 884.3 kb | Distal (>10kb) Multiome | 285 | |
| chr1:7,680,111–7,680,720 | 895.0 kb | Distal (>10kb) Multiome | 466 | |
| chr1:7,703,734–7,704,990 | 919.2 kb | Distal (>10kb) Multiome | 419 | |
| chr1:7,770,840–7,771,872 | 985.8 kb | Distal (>10kb) Multiome HiCAR | 711 | |
| chr1:7,783,377–7,785,071 | 998.5 kb | Distal (>10kb) Multiome | 618 | |
| chr1:7,885,362–7,886,254 | 1100.3 kb | Distal (>10kb) Multiome HiCAR | 196 | |
| chr1:7,942,207–7,942,705 | 1157.0 kb | Distal (>10kb) Multiome | 315 | |
| chr1:7,953,925–7,954,593 | 1168.8 kb | Distal (>10kb) Multiome | 708 | |
| chr1:7,961,111–7,962,145 | 1176.1 kb | Distal (>10kb) Multiome HiCAR | 1012 |
Genomic view of the CAMTA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.