The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CAMLG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAMLG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAMLG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:134,465,626–134,467,213 | 272.6 kb | Distal (>10kb) Multiome | 926 | |
| chr5:134,506,114–134,506,990 | 232.2 kb | Distal (>10kb) Multiome | 644 | |
| chr5:134,511,761–134,512,800 | 226.2 kb | Distal (>10kb) Multiome | 505 | |
| chr5:134,523,964–134,528,361 | 210.9 kb | Distal (>10kb) Multiome | 1077 | |
| chr5:134,539,671–134,540,206 | 198.6 kb | Distal (>10kb) Multiome | 144 | |
| chr5:134,586,828–134,587,543 | 151.3 kb | Distal (>10kb) Multiome | 407 | |
| chr5:134,632,348–134,633,007 | 105.7 kb | Distal (>10kb) Multiome | 1019 | |
| chr5:134,648,377–134,649,305 | 89.7 kb | Distal (>10kb) Multiome | 995 | |
| chr5:134,737,780–134,739,410 | 122 bp | At TSS Multiome | 1014 | |
| chr5:134,758,294–134,759,262 | 20.2 kb | Distal (>10kb) Multiome | 1011 | |
| chr5:134,845,740–134,846,572 | 107.5 kb | Distal (>10kb) Multiome | 923 | |
| chr5:134,873,977–134,874,865 | 135.8 kb | Distal (>10kb) Multiome | 978 | |
| chr5:134,904,363–134,905,880 | 166.4 kb | Distal (>10kb) Multiome HiCAR | 1005 | |
| chr5:134,990,227–134,990,750 | 251.9 kb | Distal (>10kb) Multiome | 31 | |
| chr5:135,028,731–135,029,454 | 290.7 kb | Distal (>10kb) Multiome | 166 | |
| chr5:135,030,853–135,031,806 | 292.9 kb | Distal (>10kb) Multiome | 138 | |
| chr5:135,033,567–135,034,894 | 296.0 kb | Distal (>10kb) Multiome | 630 |
Genomic view of the CAMLG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.