Predicted to enable calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytoplasmic vesicle membrane and plasma membrane. Predicted to be active in cytoplasm; glutamatergic synapse; and postsynapse. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CAMKV. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAMKV upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAMKV, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:49,718,116–49,720,106 | 150.3 kb | Distal (>10kb) Multiome | 450 | |
| chr3:49,723,361–49,724,517 | 145.8 kb | Distal (>10kb) Multiome | 769 | |
| chr3:49,785,831–49,787,202 | 83.3 kb | Distal (>10kb) Multiome | 854 | |
| chr3:49,802,203–49,804,006 | 67.0 kb | Distal (>10kb) Multiome | 733 | |
| chr3:49,856,099–49,857,163 | 13.3 kb | Distal (>10kb) Multiome | 664 | |
| chr3:49,869,590–49,870,249 | 108 bp | At TSS Multiome | 251 | |
| chr3:49,903,411–49,904,277 | 34.0 kb | Distal (>10kb) Multiome | 415 | |
| chr3:49,929,290–49,930,212 | 59.9 kb | Distal (>10kb) Multiome | 799 | |
| chr3:49,939,635–49,940,747 | 70.2 kb | Distal (>10kb) Multiome | 949 | |
| chr3:50,088,748–50,089,596 | 219.0 kb | Distal (>10kb) Multiome | 677 | |
| chr3:50,121,279–50,122,037 | 251.8 kb | Distal (>10kb) Multiome | 364 | |
| chr3:50,154,437–50,155,741 | 285.1 kb | Distal (>10kb) Multiome | 450 |
Genomic view of the CAMKV locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.