The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CAMK4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAMK4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAMK4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:111,069,762–111,071,332 | 153.6 kb | Distal (>10kb) Multiome | 267 | |
| chr5:111,072,593–111,073,857 | 151.1 kb | Distal (>10kb) Multiome | 461 | |
| chr5:111,092,062–111,092,844 | 132.1 kb | Distal (>10kb) Multiome | 1173 | |
| chr5:111,214,314–111,214,666 | 9.7 kb | Proximal (<10kb) | 8 | |
| chr5:111,223,414–111,225,205 | 92 bp | At TSS Multiome | 593 | |
| chr5:111,227,940–111,228,140 | 3.6 kb | Proximal (<10kb) | 92 | |
| chr5:111,447,496–111,448,355 | 223.5 kb | Distal (>10kb) Multiome | 259 | |
| chr5:111,511,588–111,513,437 | 288.2 kb | Distal (>10kb) Multiome | 1035 |
Genomic view of the CAMK4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.