The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for CALU. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CALU upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CALU, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:128,454,251–128,454,939 | 284.8 kb | Distal (>10kb) Multiome | 220 | |
| chr7:128,455,301–128,456,353 | 283.5 kb | Distal (>10kb) Multiome | 875 | |
| chr7:128,476,406–128,477,319 | 262.6 kb | Distal (>10kb) Multiome | 616 | |
| chr7:128,530,813–128,532,054 | 208.1 kb | Distal (>10kb) Multiome | 421 | |
| chr7:128,697,256–128,697,860 | 41.8 kb | Distal (>10kb) Multiome | 373 | |
| chr7:128,738,818–128,739,927 | 75 bp | At TSS Multiome | 899 | |
| chr7:128,782,847–128,783,828 | 44.0 kb | Distal (>10kb) Multiome | 559 | |
| chr7:128,790,457–128,792,157 | 52.0 kb | Distal (>10kb) Multiome | 579 | |
| chr7:128,831,024–128,832,923 | 93.3 kb | Distal (>10kb) Multiome | 529 | |
| chr7:128,842,024–128,842,470 | 102.9 kb | Distal (>10kb) Multiome | 308 | |
| chr7:128,862,244–128,863,913 | 123.4 kb | Distal (>10kb) Multiome | 736 | |
| chr7:128,868,986–128,870,326 | 130.3 kb | Distal (>10kb) Multiome | 557 | |
| chr7:128,879,898–128,880,508 | 140.8 kb | Distal (>10kb) Multiome | 323 | |
| chr7:128,890,731–128,891,934 | 152.0 kb | Distal (>10kb) Multiome | 231 | |
| chr7:128,911,320–128,912,136 | 172.3 kb | Distal (>10kb) Multiome | 216 | |
| chr7:128,937,568–128,938,346 | 198.6 kb | Distal (>10kb) Multiome | 392 |
Genomic view of the CALU locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.