This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for CALCOCO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CALCOCO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CALCOCO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:48,543,214–48,543,984 | 287.5 kb | Distal (>10kb) Multiome | 355 | |
| chr17:48,578,092–48,578,728 | 252.7 kb | Distal (>10kb) Multiome | 324 | |
| chr17:48,610,274–48,610,853 | 220.2 kb | Distal (>10kb) Multiome | 450 | |
| chr17:48,671,728–48,672,690 | 158.5 kb | Distal (>10kb) Multiome | 409 | |
| chr17:48,678,104–48,678,743 | 152.5 kb | Distal (>10kb) Multiome | 453 | |
| chr17:48,718,468–48,719,563 | 112.2 kb | Distal (>10kb) Multiome | 164 | |
| chr17:48,719,708–48,720,337 | 111.0 kb | Distal (>10kb) Multiome | 181 | |
| chr17:48,722,219–48,723,762 | 108.1 kb | Distal (>10kb) Multiome | 220 | |
| chr17:48,728,286–48,729,570 | 102.1 kb | Distal (>10kb) Multiome | 376 | |
| chr17:48,816,754–48,817,592 | 13.8 kb | Distal (>10kb) Multiome | 589 | |
| chr17:48,830,670–48,831,519 | 39 bp | At TSS Multiome | 838 | |
| chr17:48,891,910–48,893,540 | 61.6 kb | Distal (>10kb) Multiome | 1059 | |
| chr17:48,907,825–48,909,317 | 77.3 kb | Distal (>10kb) Multiome | 1011 | |
| chr17:48,944,483–48,945,203 | 113.8 kb | Distal (>10kb) Multiome | 1009 | |
| chr17:48,995,124–48,997,874 | 166.4 kb | Distal (>10kb) Multiome | 1057 | |
| chr17:49,013,253–49,014,714 | 183.0 kb | Distal (>10kb) Multiome | 480 | |
| chr17:49,022,149–49,022,993 | 191.6 kb | Distal (>10kb) Multiome | 306 | |
| chr17:49,031,811–49,032,444 | 201.3 kb | Distal (>10kb) Multiome | 423 | |
| chr17:49,035,641–49,036,299 | 205.0 kb | Distal (>10kb) Multiome | 338 |
Genomic view of the CALCOCO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.