Enables hormone activity. Involved in calcitonin gene-related peptide receptor signaling pathway. Is active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CALCB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CALCB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CALCB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:14,519,723–14,521,072 | 384.6 kb | Distal (>10kb) Multiome HiCAR | 1010 | |
| chr11:14,643,085–14,645,138 | 261.2 kb | Distal (>10kb) Multiome | 880 | |
| chr11:14,791,132–14,791,866 | 113.4 kb | Distal (>10kb) Multiome | 119 | |
| chr11:14,855,765–14,856,853 | 48.8 kb | Distal (>10kb) Multiome | 173 | |
| chr11:14,886,335–14,887,322 | 18.3 kb | Distal (>10kb) Multiome | 149 | |
| chr11:14,890,942–14,892,679 | 12.8 kb | Distal (>10kb) Multiome | 910 | |
| chr11:14,904,700–14,906,451 | 542 bp | At TSS Multiome | 355 | |
| chr11:14,907,367–14,908,221 | 2.8 kb | Proximal (<10kb) Multiome | 310 | |
| chr11:14,969,633–14,970,312 | 65.0 kb | Distal (>10kb) Multiome | 102 | |
| chr11:14,973,534–14,975,581 | 70.0 kb | Distal (>10kb) Multiome | 299 | |
| chr11:15,034,736–15,035,654 | 130.4 kb | Distal (>10kb) Multiome | 161 | |
| chr11:15,073,189–15,075,422 | 170.0 kb | Distal (>10kb) Multiome | 538 |
Genomic view of the CALCB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.