Enables RNA binding activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of cytokine production; and negative regulation of signal transduction. Located in cytosol and nuclear speck. Part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CACTIN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CACTIN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CACTIN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:3,360,114–3,360,563 | 266.5 kb | Distal (>10kb) Multiome | 430 | |
| chr19:3,434,837–3,435,636 | 191.6 kb | Distal (>10kb) Multiome | 777 | |
| chr19:3,441,686–3,442,206 | 184.8 kb | Distal (>10kb) Multiome | 86 | |
| chr19:3,444,085–3,444,710 | 182.3 kb | Distal (>10kb) Multiome | 150 | |
| chr19:3,500,403–3,501,074 | 126.0 kb | Distal (>10kb) Multiome | 886 | |
| chr19:3,505,575–3,507,061 | 120.7 kb | Distal (>10kb) Multiome | 838 | |
| chr19:3,557,019–3,558,238 | 69.1 kb | Distal (>10kb) Multiome | 811 | |
| chr19:3,572,147–3,574,664 | 54.1 kb | Distal (>10kb) Multiome | 737 | |
| chr19:3,576,363–3,578,543 | 48.5 kb | Distal (>10kb) Multiome | 346 | |
| chr19:3,606,342–3,607,177 | 20.0 kb | Distal (>10kb) Multiome | 377 | |
| chr19:3,626,518–3,627,304 | 245 bp | At TSS Multiome | 833 | |
| chr19:3,699,968–3,700,899 | 73.7 kb | Distal (>10kb) Multiome | 489 | |
| chr19:3,721,462–3,721,997 | 94.8 kb | Distal (>10kb) Multiome | 760 | |
| chr19:3,722,652–3,723,093 | 96.2 kb | Distal (>10kb) Multiome | 106 | |
| chr19:3,761,103–3,762,150 | 134.8 kb | Distal (>10kb) Multiome | 839 | |
| chr19:3,762,300–3,763,344 | 136.1 kb | Distal (>10kb) Multiome | 817 | |
| chr19:3,786,012–3,786,456 | 159.4 kb | Distal (>10kb) Multiome | 237 | |
| chr19:3,868,451–3,869,181 | 242.2 kb | Distal (>10kb) Multiome | 233 |
Genomic view of the CACTIN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.