This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CACNA2D3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CACNA2D3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CACNA2D3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:53,842,545–53,843,152 | 279.8 kb | Distal (>10kb) Multiome | 473 | |
| chr3:53,845,424–53,846,842 | 276.2 kb | Distal (>10kb) Multiome | 849 | |
| chr3:53,881,538–53,882,565 | 240.4 kb | Distal (>10kb) Multiome | 818 | |
| chr3:53,891,162–53,892,300 | 230.6 kb | Distal (>10kb) Multiome | 760 | |
| chr3:53,938,728–53,939,694 | 183.4 kb | Distal (>10kb) Multiome | 239 | |
| chr3:54,087,508–54,088,258 | 34.7 kb | Distal (>10kb) Multiome | 177 | |
| chr3:54,120,980–54,123,073 | 357 bp | At TSS Multiome | 295 | |
| chr3:54,322,075–54,322,792 | 200.0 kb | Distal (>10kb) Multiome | 210 | |
| chr3:56,122,772–56,123,398 | 2000.5 kb | Distal (>10kb) Multiome HiCAR | 35 |
Genomic view of the CACNA2D3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.