Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for CACNA1G. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CACNA1G upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CACNA1G, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:50,273,066–50,273,646 | 287.5 kb | Distal (>10kb) Multiome | 411 | |
| chr17:50,274,084–50,274,945 | 286.2 kb | Distal (>10kb) Multiome | 242 | |
| chr17:50,345,523–50,346,998 | 214.5 kb | Distal (>10kb) Multiome | 809 | |
| chr17:50,363,392–50,364,195 | 196.9 kb | Distal (>10kb) Multiome | 164 | |
| chr17:50,372,860–50,373,487 | 187.6 kb | Distal (>10kb) Multiome | 999 | |
| chr17:50,397,227–50,397,885 | 163.1 kb | Distal (>10kb) Multiome | 1045 | |
| chr17:50,425,595–50,426,626 | 134.5 kb | Distal (>10kb) Multiome | 619 | |
| chr17:50,478,411–50,479,262 | 81.9 kb | Distal (>10kb) Multiome | 956 | |
| chr17:50,508,047–50,508,856 | 52.3 kb | Distal (>10kb) Multiome | 332 | |
| chr17:50,541,672–50,542,697 | 18.6 kb | Distal (>10kb) Multiome | 772 | |
| chr17:50,546,778–50,547,615 | 13.5 kb | Distal (>10kb) Multiome | 786 | |
| chr17:50,550,779–50,551,160 | 9.6 kb | Proximal (<10kb) | 410 | |
| chr17:50,558,590–50,561,781 | 218 bp | At TSS Multiome | 587 | |
| chr17:50,634,652–50,635,325 | 74.3 kb | Distal (>10kb) Multiome | 471 | |
| chr17:50,707,179–50,708,006 | 147.0 kb | Distal (>10kb) Multiome | 1055 | |
| chr17:50,719,167–50,720,018 | 158.9 kb | Distal (>10kb) Multiome | 1050 |
Genomic view of the CACNA1G locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.