Predicted to be involved in vesicle-mediated transport. Predicted to be located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CACFD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CACFD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CACFD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:133,163,575–133,164,128 | 296.1 kb | Distal (>10kb) Multiome | 308 | |
| chr9:133,238,117–133,239,420 | 221.3 kb | Distal (>10kb) Multiome | 620 | |
| chr9:133,335,737–133,336,702 | 123.7 kb | Distal (>10kb) Multiome | 1038 | |
| chr9:133,347,434–133,348,830 | 111.8 kb | Distal (>10kb) Multiome | 893 | |
| chr9:133,356,029–133,357,223 | 103.4 kb | Distal (>10kb) Multiome | 648 | |
| chr9:133,375,394–133,376,740 | 83.8 kb | Distal (>10kb) Multiome | 834 | |
| chr9:133,417,747–133,418,516 | 41.8 kb | Distal (>10kb) Multiome | 1015 | |
| chr9:133,428,444–133,429,113 | 31.2 kb | Distal (>10kb) Multiome | 255 | |
| chr9:133,429,621–133,430,196 | 30.1 kb | Distal (>10kb) Multiome | 197 | |
| chr9:133,458,883–133,460,984 | 102 bp | At TSS Multiome | 835 | |
| chr9:133,478,485–133,479,696 | 19.2 kb | Distal (>10kb) Multiome | 653 | |
| chr9:133,608,924–133,609,730 | 149.4 kb | Distal (>10kb) Multiome | 411 | |
| chr9:133,738,059–133,738,688 | 278.4 kb | Distal (>10kb) Multiome | 451 |
Genomic view of the CACFD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.