To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for CABYR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CABYR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CABYR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:23,918,141–23,918,930 | 220.5 kb | Distal (>10kb) Multiome | 200 | |
| chr18:23,938,974–23,939,515 | 199.9 kb | Distal (>10kb) Multiome | 48 | |
| chr18:24,014,017–24,015,501 | 124.6 kb | Distal (>10kb) Multiome | 619 | |
| chr18:24,138,655–24,139,879 | 14 bp | At TSS Multiome | 483 | |
| chr18:24,176,686–24,177,648 | 38.2 kb | Distal (>10kb) Multiome | 194 | |
| chr18:24,271,142–24,272,382 | 132.9 kb | Distal (>10kb) Multiome | 485 | |
| chr18:24,368,558–24,369,702 | 230.0 kb | Distal (>10kb) Multiome | 140 | |
| chr18:24,397,168–24,398,771 | 258.9 kb | Distal (>10kb) Multiome | 651 | |
| chr18:24,426,310–24,427,225 | 287.6 kb | Distal (>10kb) Multiome | 799 |
Genomic view of the CABYR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.