Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for CABP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CABP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CABP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:120,361,277–120,362,299 | 278.8 kb | Distal (>10kb) Multiome | 308 | |
| chr12:120,368,637–120,370,303 | 271.5 kb | Distal (>10kb) Multiome | 250 | |
| chr12:120,388,762–120,389,560 | 251.4 kb | Distal (>10kb) Multiome | 178 | |
| chr12:120,394,470–120,395,052 | 245.8 kb | Distal (>10kb) Multiome | 283 | |
| chr12:120,413,842–120,414,516 | 226.4 kb | Distal (>10kb) Multiome | 289 | |
| chr12:120,437,436–120,438,568 | 202.6 kb | Distal (>10kb) Multiome | 725 | |
| chr12:120,445,927–120,446,970 | 194.2 kb | Distal (>10kb) Multiome | 982 | |
| chr12:120,468,864–120,470,390 | 170.8 kb | Distal (>10kb) Multiome | 942 | |
| chr12:120,495,362–120,496,939 | 144.6 kb | Distal (>10kb) Multiome | 794 | |
| chr12:120,528,856–120,529,468 | 111.5 kb | Distal (>10kb) Multiome | 849 | |
| chr12:120,534,230–120,535,077 | 106.1 kb | Distal (>10kb) Multiome | 730 | |
| chr12:120,580,919–120,581,830 | 59.2 kb | Distal (>10kb) Multiome HiCAR | 736 | |
| chr12:120,584,329–120,585,045 | 55.8 kb | Distal (>10kb) Multiome HiCAR | 460 | |
| chr12:120,638,432–120,638,871 | 1.8 kb | Proximal (<10kb) | 23 | |
| chr12:120,640,005–120,641,704 | 943 bp | At TSS Multiome | 562 | |
| chr12:120,647,006–120,647,207 | 6.4 kb | Proximal (<10kb) | 305 | |
| chr12:120,648,914–120,649,665 | 8.6 kb | Proximal (<10kb) Multiome | 405 | |
| chr12:120,668,575–120,669,135 | 28.2 kb | Distal (>10kb) Multiome | 98 | |
| chr12:120,686,185–120,687,741 | 46.1 kb | Distal (>10kb) Multiome HiCAR | 1030 | |
| chr12:120,710,025–120,711,277 | 69.7 kb | Distal (>10kb) Multiome HiCAR | 573 | |
| chr12:120,725,271–120,726,309 | 85.2 kb | Distal (>10kb) Multiome HiCAR | 663 | |
| chr12:120,903,538–120,904,786 | 263.8 kb | Distal (>10kb) Multiome | 749 |
Genomic view of the CABP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.