Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for CABIN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CABIN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CABIN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:23,716,825–23,717,722 | 294.0 kb | Distal (>10kb) Multiome | 846 | |
| chr22:23,750,563–23,751,795 | 260.2 kb | Distal (>10kb) Multiome | 687 | |
| chr22:23,767,199–23,768,799 | 243.1 kb | Distal (>10kb) Multiome | 812 | |
| chr22:23,772,486–23,773,491 | 238.5 kb | Distal (>10kb) Multiome | 415 | |
| chr22:23,786,359–23,787,793 | 224.1 kb | Distal (>10kb) Multiome | 723 | |
| chr22:23,789,208–23,789,944 | 221.9 kb | Distal (>10kb) Multiome | 146 | |
| chr22:23,804,750–23,805,326 | 206.4 kb | Distal (>10kb) Multiome | 44 | |
| chr22:23,838,611–23,839,672 | 172.2 kb | Distal (>10kb) Multiome | 472 | |
| chr22:23,849,291–23,849,993 | 161.7 kb | Distal (>10kb) Multiome | 577 | |
| chr22:23,856,822–23,858,514 | 153.5 kb | Distal (>10kb) Multiome | 735 | |
| chr22:23,893,788–23,895,770 | 115.8 kb | Distal (>10kb) Multiome | 932 | |
| chr22:23,913,645–23,914,284 | 97.3 kb | Distal (>10kb) Multiome | 787 | |
| chr22:23,956,273–23,956,867 | 54.8 kb | Distal (>10kb) Multiome | 182 | |
| chr22:24,010,924–24,011,936 | 60 bp | At TSS Multiome | 796 | |
| chr22:24,155,850–24,157,427 | 145.8 kb | Distal (>10kb) Multiome | 647 | |
| chr22:24,270,283–24,271,594 | 259.5 kb | Distal (>10kb) Multiome | 875 |
Genomic view of the CABIN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.