Transcription factors with Perturb-seq knockdown data for C8orf76. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C8orf76 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C8orf76, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:123,041,536–123,042,890 | 199.1 kb | Distal (>10kb) Multiome | 925 | |
| chr8:123,065,582–123,066,386 | 175.3 kb | Distal (>10kb) Multiome | 354 | |
| chr8:123,072,367–123,073,561 | 168.7 kb | Distal (>10kb) Multiome | 858 | |
| chr8:123,156,604–123,157,953 | 84.1 kb | Distal (>10kb) Multiome | 1083 | |
| chr8:123,160,441–123,161,547 | 80.7 kb | Distal (>10kb) Multiome | 590 | |
| chr8:123,205,121–123,205,789 | 35.9 kb | Distal (>10kb) Multiome | 298 | |
| chr8:123,207,081–123,207,716 | 34.0 kb | Distal (>10kb) Multiome | 96 | |
| chr8:123,235,684–123,236,295 | 5.4 kb | Proximal (<10kb) Multiome | 110 | |
| chr8:123,240,791–123,241,581 | 24 bp | At TSS Multiome | 784 | |
| chr8:123,273,286–123,275,625 | 33.4 kb | Distal (>10kb) Multiome | 970 | |
| chr8:123,395,612–123,397,193 | 155.2 kb | Distal (>10kb) Multiome | 1096 | |
| chr8:123,416,006–123,417,726 | 175.2 kb | Distal (>10kb) Multiome | 823 | |
| chr8:123,479,357–123,480,359 | 238.4 kb | Distal (>10kb) Multiome | 179 | |
| chr8:123,539,997–123,542,004 | 300.1 kb | Distal (>10kb) Multiome | 699 | |
| chr8:124,473,813–124,475,636 | 1233.4 kb | Distal (>10kb) Multiome HiCAR | 970 |
Genomic view of the C8orf76 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.