Transcription factors with Perturb-seq knockdown data for C7orf25. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C7orf25 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C7orf25, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:42,887,741–42,889,424 | 23.6 kb | Distal (>10kb) Multiome | 819 | |
| chr7:42,911,366–42,912,538 | 56 bp | At TSS Multiome | 975 | |
| chr7:42,931,754–42,932,671 | 20.2 kb | Distal (>10kb) Multiome | 701 | |
| chr7:43,108,219–43,108,698 | 196.4 kb | Distal (>10kb) Multiome | 184 | |
| chr7:43,112,283–43,114,054 | 201.1 kb | Distal (>10kb) Multiome | 392 |
Genomic view of the C7orf25 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.