Predicted to act upstream of or within blastocyst hatching. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C6orf141. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C6orf141 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C6orf141, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:49,342,385–49,343,145 | 208.1 kb | Distal (>10kb) Multiome | 169 | |
| chr6:49,462,484–49,464,008 | 87.4 kb | Distal (>10kb) Multiome | 927 | |
| chr6:49,549,719–49,551,970 | 178 bp | At TSS Multiome | 616 | |
| chr6:49,556,547–49,557,111 | 5.9 kb | Proximal (<10kb) | 435 | |
| chr6:49,557,381–49,557,797 | 6.7 kb | Proximal (<10kb) | 54 | |
| chr6:50,030,465–50,031,474 | 480.3 kb | Distal (>10kb) Multiome HiCAR | 317 |
Genomic view of the C6orf141 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.