Transcription factors with Perturb-seq knockdown data for C4orf19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C4orf19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C4orf19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:37,243,112–37,245,862 | 210.0 kb | Distal (>10kb) Multiome | 350 | |
| chr4:37,452,983–37,454,151 | 61 bp | At TSS Multiome | 642 | |
| chr4:37,463,590–37,463,758 | 9.7 kb | Proximal (<10kb) | 23 | |
| chr4:37,653,460–37,654,106 | 199.9 kb | Distal (>10kb) Multiome | 164 | |
| chr4:37,685,221–37,687,509 | 232.7 kb | Distal (>10kb) Multiome | 846 | |
| chr4:37,711,861–37,713,394 | 258.9 kb | Distal (>10kb) Multiome | 94 | |
| chr4:37,825,715–37,827,578 | 372.7 kb | Distal (>10kb) Multiome HiCAR | 884 |
Genomic view of the C4orf19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.