Transcription factors with Perturb-seq knockdown data for C2CD4D-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C2CD4D-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C2CD4D-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:151,611,789–151,613,070 | 229.8 kb | Distal (>10kb) Multiome | 761 | |
| chr1:151,721,370–151,721,843 | 120.3 kb | Distal (>10kb) Multiome | 186 | |
| chr1:151,762,987–151,763,859 | 78.4 kb | Distal (>10kb) Multiome | 848 | |
| chr1:151,790,055–151,791,612 | 51.3 kb | Distal (>10kb) Multiome | 953 | |
| chr1:151,836,313–151,836,752 | 5.1 kb | Proximal (<10kb) | 359 | |
| chr1:151,837,933–151,839,171 | 2.7 kb | Proximal (<10kb) | 219 | |
| chr1:151,839,238–151,840,386 | 2.1 kb | Proximal (<10kb) Multiome | 493 | |
| chr1:151,909,150–151,910,123 | 67.7 kb | Distal (>10kb) Multiome | 983 | |
| chr1:151,992,346–151,994,801 | 150.7 kb | Distal (>10kb) Multiome | 709 | |
| chr1:152,036,267–152,037,471 | 195.1 kb | Distal (>10kb) Multiome | 586 | |
| chr1:152,047,642–152,048,726 | 206.3 kb | Distal (>10kb) Multiome | 810 |
Genomic view of the C2CD4D-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.