Enables RNA binding activity. Predicted to be located in extracellular region; ficolin-1-rich granule lumen; and secretory granule lumen. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C1orf35. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C1orf35 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C1orf35, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:227,946,348–227,948,809 | 156.7 kb | Distal (>10kb) Multiome | 645 | |
| chr1:228,004,351–228,004,883 | 98.9 kb | Distal (>10kb) Multiome | 154 | |
| chr1:228,058,680–228,061,126 | 43.6 kb | Distal (>10kb) Multiome | 377 | |
| chr1:228,081,634–228,083,952 | 20.8 kb | Distal (>10kb) Multiome | 942 | |
| chr1:228,085,140–228,085,832 | 18.0 kb | Distal (>10kb) Multiome | 276 | |
| chr1:228,101,882–228,103,743 | 1.2 kb | Proximal (<10kb) Multiome | 929 | |
| chr1:228,108,924–228,110,105 | 6.0 kb | Proximal (<10kb) Multiome | 958 | |
| chr1:228,130,684–228,131,457 | 27.6 kb | Distal (>10kb) Multiome | 488 | |
| chr1:228,139,579–228,140,870 | 36.7 kb | Distal (>10kb) Multiome | 931 | |
| chr1:228,164,898–228,166,840 | 62.4 kb | Distal (>10kb) Multiome | 1011 | |
| chr1:228,174,477–228,174,893 | 71.2 kb | Distal (>10kb) Multiome | 254 | |
| chr1:228,212,247–228,214,390 | 110.3 kb | Distal (>10kb) Multiome | 604 | |
| chr1:228,275,524–228,276,595 | 172.6 kb | Distal (>10kb) Multiome | 428 | |
| chr1:228,378,133–228,379,597 | 275.2 kb | Distal (>10kb) Multiome | 515 |
Genomic view of the C1orf35 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.