Transcription factors with Perturb-seq knockdown data for C1orf226. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C1orf226 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C1orf226, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:162,372,665–162,373,101 | 8.6 kb | Proximal (<10kb) | 300 | |
| chr1:162,377,888–162,378,171 | 3.6 kb | Proximal (<10kb) | 18 | |
| chr1:162,391,046–162,391,583 | 9.3 kb | Proximal (<10kb) | 26 | |
| chr1:162,391,686–162,392,380 | 10.0 kb | Proximal (<10kb) | 276 |
Genomic view of the C1orf226 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.