This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for C1S. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C1S upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C1S, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:6,763,677–6,764,983 | 296.3 kb | Distal (>10kb) Multiome | 570 | |
| chr12:6,765,172–6,767,791 | 294.4 kb | Distal (>10kb) Multiome | 824 | |
| chr12:6,768,329–6,769,331 | 291.6 kb | Distal (>10kb) Multiome | 249 | |
| chr12:6,778,736–6,779,459 | 281.7 kb | Distal (>10kb) Multiome | 777 | |
| chr12:6,821,268–6,822,155 | 239.0 kb | Distal (>10kb) Multiome | 299 | |
| chr12:6,825,458–6,825,915 | 235.0 kb | Distal (>10kb) Multiome | 404 | |
| chr12:6,828,101–6,829,966 | 231.1 kb | Distal (>10kb) Multiome | 689 | |
| chr12:6,851,017–6,853,279 | 208.4 kb | Distal (>10kb) Multiome | 966 | |
| chr12:6,866,801–6,870,175 | 193.2 kb | Distal (>10kb) Multiome | 887 | |
| chr12:6,871,062–6,874,199 | 188.4 kb | Distal (>10kb) Multiome | 947 | |
| chr12:6,890,735–6,891,820 | 169.5 kb | Distal (>10kb) Multiome | 908 | |
| chr12:6,904,217–6,905,282 | 155.9 kb | Distal (>10kb) Multiome | 566 | |
| chr12:6,914,274–6,914,898 | 146.3 kb | Distal (>10kb) Multiome | 536 | |
| chr12:6,924,156–6,924,592 | 136.2 kb | Distal (>10kb) Multiome | 458 | |
| chr12:6,925,828–6,926,431 | 134.7 kb | Distal (>10kb) Multiome | 407 | |
| chr12:6,927,411–6,928,051 | 132.9 kb | Distal (>10kb) Multiome | 493 | |
| chr12:6,936,709–6,938,342 | 122.7 kb | Distal (>10kb) Multiome | 1008 | |
| chr12:6,942,356–6,945,492 | 116.5 kb | Distal (>10kb) Multiome | 1205 | |
| chr12:6,945,587–6,947,099 | 114.3 kb | Distal (>10kb) Multiome | 618 | |
| chr12:6,961,769–6,963,542 | 97.5 kb | Distal (>10kb) Multiome | 682 | |
| chr12:6,964,932–6,965,569 | 95.5 kb | Distal (>10kb) Multiome | 549 | |
| chr12:6,970,111–6,971,189 | 90.0 kb | Distal (>10kb) Multiome | 899 | |
| chr12:7,018,028–7,019,126 | 42.0 kb | Distal (>10kb) Multiome HiCAR | 824 | |
| chr12:7,108,059–7,109,582 | 48.6 kb | Distal (>10kb) Multiome | 818 | |
| chr12:7,129,788–7,131,412 | 69.6 kb | Distal (>10kb) Multiome | 619 | |
| chr12:7,188,394–7,190,508 | 127.8 kb | Distal (>10kb) Multiome | 769 |
Genomic view of the C1S locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.