The protein encoded by this gene has been shown to be upregulated in SV40-immortalized fibroblasts as well as in endometrial carcinoma cells. The encoded protein is found primarily in the nucleus. This protein may play a role in placental development and diseases such as pre-eclampsia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for C19orf33. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C19orf33 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C19orf33, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:38,004,389–38,004,823 | 299.5 kb | Distal (>10kb) Multiome | 367 | |
| chr19:38,043,611–38,044,643 | 260.4 kb | Distal (>10kb) Multiome | 66 | |
| chr19:38,074,116–38,074,898 | 229.7 kb | Distal (>10kb) Multiome | 299 | |
| chr19:38,183,265–38,183,970 | 120.6 kb | Distal (>10kb) Multiome | 156 | |
| chr19:38,223,967–38,224,571 | 79.9 kb | Distal (>10kb) Multiome | 677 | |
| chr19:38,229,570–38,230,021 | 74.5 kb | Distal (>10kb) Multiome | 354 | |
| chr19:38,255,918–38,256,778 | 47.7 kb | Distal (>10kb) Multiome | 371 | |
| chr19:38,263,873–38,265,423 | 39.7 kb | Distal (>10kb) Multiome | 590 | |
| chr19:38,304,071–38,305,583 | 972 bp | At TSS Multiome | 531 | |
| chr19:38,315,514–38,316,642 | 11.8 kb | Distal (>10kb) Multiome | 747 | |
| chr19:38,319,279–38,320,342 | 15.7 kb | Distal (>10kb) Multiome | 359 | |
| chr19:38,335,358–38,337,514 | 31.5 kb | Distal (>10kb) Multiome | 898 | |
| chr19:38,361,454–38,362,809 | 57.9 kb | Distal (>10kb) Multiome | 604 | |
| chr19:38,374,176–38,375,269 | 70.4 kb | Distal (>10kb) Multiome | 1041 | |
| chr19:38,385,485–38,386,937 | 81.7 kb | Distal (>10kb) Multiome | 156 | |
| chr19:38,387,065–38,389,471 | 83.9 kb | Distal (>10kb) Multiome | 591 | |
| chr19:38,394,369–38,395,035 | 90.4 kb | Distal (>10kb) Multiome | 191 | |
| chr19:38,402,504–38,403,738 | 98.8 kb | Distal (>10kb) Multiome | 940 | |
| chr19:38,417,766–38,418,568 | 113.9 kb | Distal (>10kb) Multiome | 407 | |
| chr19:38,434,539–38,435,128 | 130.6 kb | Distal (>10kb) Multiome | 238 | |
| chr19:38,452,620–38,453,510 | 148.9 kb | Distal (>10kb) Multiome | 355 | |
| chr19:38,506,710–38,507,745 | 203.0 kb | Distal (>10kb) Multiome | 369 | |
| chr19:38,514,956–38,515,568 | 211.0 kb | Distal (>10kb) Multiome | 404 | |
| chr19:38,565,090–38,565,701 | 261.1 kb | Distal (>10kb) Multiome | 164 | |
| chr19:38,595,857–38,597,322 | 292.2 kb | Distal (>10kb) Multiome | 478 |
Genomic view of the C19orf33 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.