Predicted to act upstream of or within negative regulation of cell population proliferation. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C18orf54. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C18orf54 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C18orf54, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:54,223,556–54,225,199 | 133.2 kb | Distal (>10kb) Multiome | 810 | |
| chr18:54,235,612–54,236,484 | 121.8 kb | Distal (>10kb) Multiome | 178 | |
| chr18:54,246,611–54,248,045 | 110.7 kb | Distal (>10kb) Multiome | 501 | |
| chr18:54,268,849–54,270,571 | 88.3 kb | Distal (>10kb) Multiome | 936 | |
| chr18:54,357,058–54,358,694 | 31 bp | At TSS Multiome | 739 | |
| chr18:54,480,384–54,481,350 | 122.9 kb | Distal (>10kb) Multiome | 108 | |
| chr18:54,528,914–54,529,969 | 171.5 kb | Distal (>10kb) Multiome | 181 | |
| chr18:54,531,114–54,532,495 | 173.7 kb | Distal (>10kb) Multiome | 125 | |
| chr18:54,606,859–54,608,069 | 249.7 kb | Distal (>10kb) Multiome | 298 |
Genomic view of the C18orf54 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.