Transcription factors with Perturb-seq knockdown data for C18orf21. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C18orf21 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C18orf21, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:35,827,502–35,828,102 | 144.9 kb | Distal (>10kb) Multiome | 227 | |
| chr18:35,849,802–35,850,882 | 122.4 kb | Distal (>10kb) Multiome | 177 | |
| chr18:35,851,060–35,852,119 | 121.1 kb | Distal (>10kb) Multiome | 244 | |
| chr18:35,949,718–35,950,700 | 22.3 kb | Distal (>10kb) Multiome | 420 | |
| chr18:35,971,798–35,973,006 | 116 bp | At TSS Multiome | 1056 | |
| chr18:36,066,875–36,067,975 | 94.9 kb | Distal (>10kb) Multiome | 832 | |
| chr18:36,128,266–36,130,354 | 156.9 kb | Distal (>10kb) Multiome | 1064 | |
| chr18:36,186,392–36,188,500 | 214.9 kb | Distal (>10kb) Multiome | 747 |
Genomic view of the C18orf21 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.