Enables identical protein binding activity. Predicted to be involved in chromatin organization. Located in cytosol and nucleoplasm. Part of MLL1 complex and NURF complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C17orf49. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C17orf49 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C17orf49, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:6,650,954–6,652,333 | 363.1 kb | Distal (>10kb) Multiome HiCAR | 949 | |
| chr17:6,831,647–6,832,107 | 182.9 kb | Distal (>10kb) Multiome | 202 | |
| chr17:6,995,886–6,996,299 | 18.8 kb | Distal (>10kb) Multiome | 124 | |
| chr17:7,012,245–7,012,890 | 2.2 kb | Proximal (<10kb) Multiome | 804 | |
| chr17:7,014,335–7,015,213 | 76 bp | At TSS Multiome | 842 | |
| chr17:7,019,807–7,020,192 | 5.1 kb | Proximal (<10kb) | 234 | |
| chr17:7,021,831–7,024,265 | 9.1 kb | Proximal (<10kb) Multiome | 614 | |
| chr17:7,035,527–7,036,637 | 21.2 kb | Distal (>10kb) Multiome | 791 | |
| chr17:7,132,532–7,133,109 | 118.0 kb | Distal (>10kb) Multiome | 312 | |
| chr17:7,177,263–7,177,909 | 162.8 kb | Distal (>10kb) Multiome | 453 | |
| chr17:7,204,820–7,205,551 | 190.4 kb | Distal (>10kb) Multiome | 364 | |
| chr17:7,207,943–7,208,476 | 193.5 kb | Distal (>10kb) Multiome | 91 | |
| chr17:7,213,858–7,216,461 | 199.7 kb | Distal (>10kb) Multiome | 737 | |
| chr17:7,219,603–7,220,515 | 205.2 kb | Distal (>10kb) Multiome | 793 | |
| chr17:7,233,847–7,235,210 | 219.8 kb | Distal (>10kb) Multiome | 1020 | |
| chr17:7,237,531–7,238,757 | 223.2 kb | Distal (>10kb) Multiome | 502 | |
| chr17:7,238,867–7,240,155 | 224.9 kb | Distal (>10kb) Multiome | 783 | |
| chr17:7,241,494–7,243,462 | 228.3 kb | Distal (>10kb) Multiome | 1037 | |
| chr17:7,251,263–7,252,962 | 237.4 kb | Distal (>10kb) Multiome | 985 | |
| chr17:7,260,746–7,263,748 | 247.8 kb | Distal (>10kb) Multiome | 639 | |
| chr17:7,280,161–7,282,555 | 266.9 kb | Distal (>10kb) Multiome | 841 | |
| chr17:7,293,901–7,295,189 | 280.0 kb | Distal (>10kb) Multiome | 443 | |
| chr17:7,296,224–7,296,683 | 281.8 kb | Distal (>10kb) Multiome | 688 | |
| chr17:7,306,788–7,309,027 | 292.6 kb | Distal (>10kb) Multiome | 896 |
Genomic view of the C17orf49 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.