Transcription factors with Perturb-seq knockdown data for C16orf95. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C16orf95 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C16orf95, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:86,554,821–86,555,589 | 762.2 kb | Distal (>10kb) Multiome HiCAR | 807 | |
| chr16:87,047,118–87,047,923 | 270.0 kb | Distal (>10kb) Multiome | 133 | |
| chr16:87,264,671–87,265,109 | 52.5 kb | Distal (>10kb) Multiome | 88 | |
| chr16:87,278,468–87,279,093 | 38.6 kb | Distal (>10kb) Multiome | 284 | |
| chr16:87,305,529–87,306,047 | 11.5 kb | Distal (>10kb) Multiome | 282 | |
| chr16:87,316,905–87,317,759 | 3 bp | At TSS Multiome | 945 | |
| chr16:87,324,784–87,325,022 | 7.4 kb | Proximal (<10kb) | 256 | |
| chr16:87,382,568–87,384,888 | 66.5 kb | Distal (>10kb) Multiome | 1122 | |
| chr16:87,388,081–87,388,660 | 71.1 kb | Distal (>10kb) Multiome | 794 | |
| chr16:87,391,244–87,393,452 | 74.8 kb | Distal (>10kb) Multiome | 1038 | |
| chr16:87,492,670–87,493,484 | 175.7 kb | Distal (>10kb) Multiome | 652 | |
| chr16:87,601,726–87,602,537 | 284.9 kb | Distal (>10kb) Multiome | 217 |
Genomic view of the C16orf95 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.