Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C12orf76. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C12orf76 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C12orf76, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:109,833,102–109,833,778 | 215.1 kb | Distal (>10kb) Multiome | 217 | |
| chr12:109,845,155–109,845,762 | 203.1 kb | Distal (>10kb) Multiome | 618 | |
| chr12:109,880,019–109,881,173 | 167.9 kb | Distal (>10kb) Multiome | 576 | |
| chr12:109,900,106–109,900,747 | 148.2 kb | Distal (>10kb) Multiome | 818 | |
| chr12:109,995,726–109,996,660 | 52.2 kb | Distal (>10kb) Multiome HiCAR | 811 | |
| chr12:109,998,999–109,999,838 | 49.3 kb | Distal (>10kb) Multiome HiCAR | 883 | |
| chr12:110,048,083–110,048,797 | 17 bp | At TSS Multiome | 921 | |
| chr12:110,107,883–110,108,523 | 59.7 kb | Distal (>10kb) Multiome HiCAR | 171 | |
| chr12:110,123,690–110,124,996 | 75.8 kb | Distal (>10kb) Multiome | 704 | |
| chr12:110,223,831–110,224,526 | 175.5 kb | Distal (>10kb) Multiome | 199 | |
| chr12:110,280,425–110,282,158 | 232.7 kb | Distal (>10kb) Multiome | 888 | |
| chr12:110,403,190–110,403,822 | 355.2 kb | Distal (>10kb) Multiome HiCAR | 779 |
Genomic view of the C12orf76 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.