Transcription factors with Perturb-seq knockdown data for C11orf71. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C11orf71 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C11orf71, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:114,219,750–114,220,331 | 180.4 kb | Distal (>10kb) Multiome | 188 | |
| chr11:114,232,562–114,233,037 | 167.7 kb | Distal (>10kb) Multiome | 66 | |
| chr11:114,280,655–114,281,133 | 119.7 kb | Distal (>10kb) Multiome | 266 | |
| chr11:114,395,816–114,396,023 | 4.5 kb | Proximal (<10kb) | 51 | |
| chr11:114,399,639–114,401,087 | 8 bp | At TSS Multiome | 1001 | |
| chr11:114,439,222–114,440,261 | 39.0 kb | Distal (>10kb) Multiome | 796 | |
| chr11:114,559,427–114,560,368 | 159.4 kb | Distal (>10kb) Multiome | 99 |
Genomic view of the C11orf71 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.