Predicted to be involved in negative regulation of mitochondrial fission and negative regulation of protein targeting to mitochondrion. Predicted to be located in cytosol and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C11orf65. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C11orf65 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C11orf65, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:108,221,947–108,224,257 | 244.7 kb | Distal (>10kb) Multiome | 939 | |
| chr11:108,467,108–108,468,105 | 30 bp | At TSS Multiome | 756 | |
| chr11:108,497,307–108,498,913 | 30.3 kb | Distal (>10kb) Multiome | 959 | |
| chr11:108,592,726–108,594,399 | 126.3 kb | Distal (>10kb) Multiome | 684 | |
| chr11:108,664,315–108,665,549 | 197.5 kb | Distal (>10kb) Multiome | 672 |
Genomic view of the C11orf65 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.