Transcription factors with Perturb-seq knockdown data for C11orf58. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C11orf58 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C11orf58, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:15,073,189–15,075,422 | 1665.1 kb | Distal (>10kb) Multiome HiCAR | 538 | |
| chr11:15,649,647–15,651,014 | 1088.4 kb | Distal (>10kb) Multiome HiCAR | 787 | |
| chr11:16,603,833–16,608,197 | 133.7 kb | Distal (>10kb) Multiome | 849 | |
| chr11:16,613,116–16,614,766 | 124.7 kb | Distal (>10kb) Multiome | 562 | |
| chr11:16,737,938–16,739,159 | 85 bp | At TSS Multiome | 894 | |
| chr11:16,824,772–16,825,501 | 86.6 kb | Distal (>10kb) Multiome | 111 | |
| chr11:16,883,061–16,883,703 | 144.8 kb | Distal (>10kb) Multiome | 186 | |
| chr11:16,924,840–16,926,923 | 187.2 kb | Distal (>10kb) Multiome | 568 | |
| chr11:16,956,235–16,957,153 | 218.2 kb | Distal (>10kb) Multiome | 281 | |
| chr11:16,959,532–16,960,122 | 221.2 kb | Distal (>10kb) Multiome | 154 | |
| chr11:16,986,876–16,987,479 | 248.6 kb | Distal (>10kb) Multiome | 258 | |
| chr11:17,013,111–17,015,356 | 274.8 kb | Distal (>10kb) Multiome | 708 |
Genomic view of the C11orf58 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.