Transcription factors with Perturb-seq knockdown data for C10orf143. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C10orf143 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C10orf143, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:128,540,856–128,541,766 | 1569.3 kb | Distal (>10kb) Multiome HiCAR | 290 | |
| chr10:129,958,664–129,960,120 | 151.5 kb | Distal (>10kb) Multiome | 209 | |
| chr10:129,962,882–129,965,582 | 146.5 kb | Distal (>10kb) Multiome | 391 | |
| chr10:129,966,749–129,967,839 | 143.6 kb | Distal (>10kb) Multiome | 84 | |
| chr10:130,105,630–130,106,130 | 4.9 kb | Proximal (<10kb) Multiome | 94 | |
| chr10:130,109,641–130,111,870 | 29 bp | At TSS Multiome | 1015 | |
| chr10:130,135,986–130,137,502 | 25.6 kb | Distal (>10kb) Multiome | 783 | |
| chr10:130,189,597–130,191,106 | 79.6 kb | Distal (>10kb) Multiome | 709 |
Genomic view of the C10orf143 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.