Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BUD13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BUD13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BUD13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:116,499,258–116,499,862 | 273.4 kb | Distal (>10kb) Multiome | 176 | |
| chr11:116,579,863–116,581,591 | 192.0 kb | Distal (>10kb) Multiome | 336 | |
| chr11:116,687,439–116,688,374 | 85.0 kb | Distal (>10kb) Multiome | 122 | |
| chr11:116,732,600–116,733,018 | 40.2 kb | Distal (>10kb) Multiome | 240 | |
| chr11:116,772,462–116,773,416 | 7 bp | At TSS Multiome | 928 | |
| chr11:116,787,704–116,788,396 | 15.1 kb | Distal (>10kb) Multiome | 597 | |
| chr11:116,791,118–116,791,887 | 18.4 kb | Distal (>10kb) Multiome | 473 | |
| chr11:116,813,255–116,814,379 | 40.8 kb | Distal (>10kb) Multiome | 206 | |
| chr11:116,835,609–116,836,611 | 63.1 kb | Distal (>10kb) Multiome | 666 | |
| chr11:117,097,570–117,099,243 | 325.5 kb | Distal (>10kb) Multiome HiCAR | 739 | |
| chr11:117,099,458–117,100,103 | 327.0 kb | Distal (>10kb) Multiome HiCAR | 62 | |
| chr11:117,178,198–117,179,718 | 405.8 kb | Distal (>10kb) Multiome HiCAR | 726 | |
| chr11:117,197,957–117,198,434 | 425.0 kb | Distal (>10kb) Multiome HiCAR | 160 | |
| chr11:117,198,962–117,199,797 | 426.3 kb | Distal (>10kb) Multiome HiCAR | 211 |
Genomic view of the BUD13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.