BTN2A2
butyrophilin subfamily 2 member A2 | BT2.2, BTF2, BTN2.2

Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Biological processes 12 terms
Expression (TPM)
BTN2A2 — as a Regulated Gene

TFs regulating BTN2A2 0 TFs

Transcription factors with Perturb-seq knockdown data for BTN2A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BTN2A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to BTN2A2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BTN2A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr6:26,087,383–26,088,017 295.4 kb Distal (>10kb) Multiome 572
chr6:26,103,452–26,105,109 279.2 kb Distal (>10kb) Multiome 1169
chr6:26,122,481–26,124,909 260.2 kb Distal (>10kb) Multiome 1216
chr6:26,156,184–26,158,744 225.1 kb Distal (>10kb) Multiome 1310
chr6:26,171,798–26,172,499 211.1 kb Distal (>10kb) Multiome 580
chr6:26,183,128–26,184,377 199.5 kb Distal (>10kb) Multiome 311
chr6:26,187,874–26,189,538 194.0 kb Distal (>10kb) Multiome 1053
chr6:26,196,695–26,197,676 185.9 kb Distal (>10kb) Multiome 842
chr6:26,198,203–26,200,197 183.7 kb Distal (>10kb) Multiome 939
chr6:26,203,791–26,205,119 178.6 kb Distal (>10kb) Multiome 1071
chr6:26,214,872–26,218,468 166.3 kb Distal (>10kb) Multiome 1096
chr6:26,223,716–26,224,480 159.1 kb Distal (>10kb) Multiome 507
chr6:26,224,856–26,226,566 157.9 kb Distal (>10kb) Multiome 451
chr6:26,239,944–26,240,920 142.8 kb Distal (>10kb) Multiome 375
chr6:26,249,682–26,251,138 132.8 kb Distal (>10kb) Multiome 731
chr6:26,251,339–26,252,079 131.4 kb Distal (>10kb) Multiome 445
chr6:26,270,815–26,273,967 110.2 kb Distal (>10kb) Multiome 742
chr6:26,285,011–26,286,121 97.5 kb Distal (>10kb) Multiome 1121
chr6:26,304,972–26,305,585 77.7 kb Distal (>10kb) Multiome 586
chr6:26,312,505–26,313,475 70.1 kb Distal (>10kb) Multiome 896
chr6:26,322,092–26,323,232 60.5 kb Distal (>10kb) Multiome 811
chr6:26,327,476–26,328,318 55.0 kb Distal (>10kb) Multiome 716
chr6:26,341,545–26,342,139 41.3 kb Distal (>10kb) Multiome 716
chr6:26,365,073–26,365,647 17.8 kb Distal (>10kb) Multiome 587
chr6:26,382,957–26,383,951 85 bp At TSS Multiome 448
chr6:26,421,258–26,421,866 38.3 kb Distal (>10kb) Multiome 473
chr6:26,457,390–26,458,395 74.7 kb Distal (>10kb) Multiome 525
chr6:26,473,842–26,474,357 91.0 kb Distal (>10kb) Multiome 487
chr6:26,520,324–26,522,398 138.9 kb Distal (>10kb) Multiome 1082
chr6:26,532,765–26,533,409 150.0 kb Distal (>10kb) Multiome 830
chr6:26,537,180–26,538,912 154.4 kb Distal (>10kb) Multiome 1114
chr6:26,550,296–26,550,971 167.6 kb Distal (>10kb) Multiome 695
chr6:26,553,165–26,553,642 170.5 kb Distal (>10kb) Multiome 561
chr6:26,556,432–26,557,038 173.4 kb Distal (>10kb) Multiome 676
chr6:26,571,613–26,572,233 188.8 kb Distal (>10kb) Multiome 861
chr6:26,595,619–26,596,282 212.8 kb Distal (>10kb) Multiome 798
chr6:26,596,497–26,597,408 213.9 kb Distal (>10kb) Multiome 940
chr6:26,659,338–26,660,351 276.6 kb Distal (>10kb) Multiome 748

Genome Browser

Genomic view of the BTN2A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr6:26,077,383 – 26,670,351
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq