This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for BTG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BTG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BTG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:91,381,167–91,382,599 | 764.2 kb | Distal (>10kb) Multiome HiCAR | 358 | |
| chr12:92,021,477–92,022,059 | 124.0 kb | Distal (>10kb) Multiome | 151 | |
| chr12:92,143,908–92,146,773 | 218 bp | At TSS Multiome | 1151 | |
| chr12:92,147,512–92,147,919 | 1.7 kb | Proximal (<10kb) | 65 | |
| chr12:92,294,455–92,295,319 | 149.1 kb | Distal (>10kb) Multiome | 93 |
Genomic view of the BTG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.