Predicted to be involved in synaptic vesicle budding from endosome and synaptic vesicle endocytosis. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BTBD8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BTBD8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BTBD8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:91,875,920–91,876,662 | 204.1 kb | Distal (>10kb) Multiome | 176 | |
| chr1:91,884,890–91,887,193 | 194.1 kb | Distal (>10kb) Multiome | 882 | |
| chr1:92,029,331–92,030,637 | 50.2 kb | Distal (>10kb) Multiome | 471 | |
| chr1:92,079,936–92,081,084 | 150 bp | At TSS Multiome | 692 | |
| chr1:92,298,519–92,299,563 | 218.6 kb | Distal (>10kb) Multiome | 840 |
Genomic view of the BTBD8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.