Predicted to be involved in neurogenesis. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BTBD6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BTBD6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BTBD6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:104,975,803–104,976,561 | 272.4 kb | Distal (>10kb) Multiome | 394 | |
| chr14:104,977,531–104,979,147 | 270.2 kb | Distal (>10kb) Multiome | 387 | |
| chr14:104,985,398–104,986,377 | 262.9 kb | Distal (>10kb) Multiome | 518 | |
| chr14:105,020,271–105,022,072 | 227.4 kb | Distal (>10kb) Multiome | 813 | |
| chr14:105,045,704–105,046,235 | 202.7 kb | Distal (>10kb) Multiome | 635 | |
| chr14:105,086,627–105,087,884 | 161.6 kb | Distal (>10kb) Multiome | 590 | |
| chr14:105,090,382–105,091,009 | 157.9 kb | Distal (>10kb) Multiome | 375 | |
| chr14:105,092,908–105,094,307 | 154.7 kb | Distal (>10kb) Multiome | 495 | |
| chr14:105,167,331–105,169,463 | 79.6 kb | Distal (>10kb) Multiome | 496 | |
| chr14:105,180,714–105,181,828 | 67.4 kb | Distal (>10kb) Multiome | 392 | |
| chr14:105,248,175–105,249,386 | 70 bp | At TSS Multiome | 403 | |
| chr14:105,299,994–105,301,984 | 52.7 kb | Distal (>10kb) Multiome | 829 | |
| chr14:105,313,768–105,315,755 | 66.0 kb | Distal (>10kb) Multiome | 584 | |
| chr14:105,352,048–105,352,515 | 103.7 kb | Distal (>10kb) Multiome | 344 | |
| chr14:105,398,137–105,398,986 | 149.9 kb | Distal (>10kb) Multiome | 870 | |
| chr14:105,411,005–105,411,818 | 162.8 kb | Distal (>10kb) Multiome | 384 | |
| chr14:105,414,940–105,415,397 | 166.5 kb | Distal (>10kb) Multiome | 447 | |
| chr14:105,419,281–105,420,109 | 171.2 kb | Distal (>10kb) Multiome | 570 | |
| chr14:105,448,471–105,448,924 | 200.1 kb | Distal (>10kb) Multiome | 304 | |
| chr14:105,473,498–105,475,498 | 225.7 kb | Distal (>10kb) Multiome | 581 | |
| chr14:105,480,543–105,482,375 | 232.4 kb | Distal (>10kb) Multiome | 784 | |
| chr14:105,485,648–105,486,379 | 237.3 kb | Distal (>10kb) Multiome | 424 | |
| chr14:105,486,576–105,487,923 | 238.6 kb | Distal (>10kb) Multiome | 369 | |
| chr14:105,489,310–105,492,133 | 242.4 kb | Distal (>10kb) Multiome | 1014 | |
| chr14:105,526,110–105,527,233 | 277.9 kb | Distal (>10kb) Multiome | 270 | |
| chr14:105,528,085–105,528,965 | 279.9 kb | Distal (>10kb) Multiome | 568 |
Genomic view of the BTBD6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.